3-Pyridinemethanamine → 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 35

HRID 3190

Reaction equation

HRID 3190 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:20](=[O:21])[N:19]([CH3:22])[C:12]2[N:13]=[C:14](SC)[N:15]=[CH:16][C:11]=2[CH:10]=1.[NH2:23][CH2:24][C:25]1[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:20](=[O:21])[N:19]([CH3:22])[C:12]2[N:13]=[C:14]([NH:23][CH2:24][C:25]3[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=3)[N:15]=[CH:16][C:11]=2[CH:10]=1

Participants

3

Reactant 2

HCID 310183-PyridinemethanamineHCID 107367016-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Product 1

HCID 53278822-aminopyrido[2,3-d]pyrimidin-7(8H)-one 35

Procedure

This compound was prepared by a procedure similar to that described in Example 49 starting with 0.165 g (0.47 mmol) of 6-(2,6-dichlorophenyl)-8-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one of Example 37 and 1.08 g (10.0 mmol) of 3-(aminomethyl)-pyridine yielding 0.053 g of pure product; mp 224°-226° C.

Workup

  1. customThis compound was prepared by a procedure similar to

Sources & evidence

ORD record
ord-f149ec04b04c43cd9da4e5fa56e0fec3
Source dataset
uspto-grants-1998_03
Patent number
US05733914

Linked notes

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