2-Methylimidazole → HCID 178432800, compound

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH2:10][C:11]1[CH:15]=CN[N:12]=1.[CH3:17][C:18]1[NH:19]C=CN=1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH2:10][C:11]1[N:12]=[C:18]([CH3:17])[NH:19][CH:15]=1

Participants

Reactant 2

HCID 127492-Methylimidazole

HCID 178520323HCID 178520323, compound

Product 1

HCID 178432800HCID 178432800, compound

Procedure

Made using the same procedure as for 1-(2,4-dichlorophenyl)-2-pyrazolylethan-1-one except that 2-methylimidazole (3.7 g, 44.8 mmol) was used in place of pyrazole. The crude residue was purified on silica gel (5% MeOH/CH2Cl2) to yield a light yellow solid.

Workup

customThe crude residue was purified on silica gel (5% MeOH/CH2Cl2)
customto yield a light yellow solid

Sources & evidence

ORD record: ord-9098966740284bbd9e6a546de674ab13
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07425557B2

Reaction notes

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