HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → N-(7-cyanomethyl-chroman-4-yl)-3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 3-Phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionic acid | HCID 45439091 | — |
| Reactant | (4-Amino-chroman-7-yl)-acetonitrile | HCID 68929026 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(7-cyanomethyl-chroman-4-yl)-3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide | HCID 68932619 | — |
Reaction Steps
To a solution of (4-amino-chroman-7-yl)-acetonitrile (Step A, 400 mg, 2.15 mmol) in CH2Cl2 (15 mL) was added 3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionic acid (802 mg, 2.15 mmol), HATU (408 mg, 1.07 mmol), EDC (453 mg, 2.36 mmol), and DIEA (0.7 mL, 4.29 mmol). The resulting mixture was stirred at RT for 18 h. Solvent was evaporated in vacuo. The residue was purified by chromatography on silica gel. Elution with CH2Cl2:MeOH mixture (95:5) gave final compound. MS m/z: 544.12 (M+H). Calc'd. for C27H24F3N3O4S-543.56.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425631B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-fbff2b1639764c1eba5441021395fb1d |
| Source note | uspto-grants-2008_09 |