1-(3-Bromopropoxy)-2,4-difluorobenzene → tert-Butyl 4-{4-[3-(2,4-difluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate
Reaction equation
[Br:22][CH2:23][CH2:24][CH2:25][O:26][c:27]1[c:28]([F:34])[cH:29][c:30]([F:33])[cH:31][cH:32]1.[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([OH:14])[cH:12][cH:13]1>>[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([O:14][CH2:23][CH2:24][CH2:25][O:26][c:27]2[c:28]([F:34])[cH:29][c:30]([F:33])[cH:31][cH:32]2)[cH:12][cH:13]1Participants
3
Sources & evidence
- ORD record
- ord-59d0e56f49d3410e9c619618eb28d0be
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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