1,3-Dichloroacetone → 4-(Chloromethyl)-2-cyclohexyl-1,3-oxazole

HRID 322267

Reaction equation

[CH:1]1([C:7]([NH2:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:10][CH2:11][C:12]([CH2:14]Cl)=O>>[Cl:10][CH2:11][C:12]1[N:9]=[C:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[O:8][CH:14]=1

Participants

Reactant 2

HCID 107931,3-Dichloroacetone

HCID 14283Cyclohexanecarboxamide

Product 1

HCID 222413794-(Chloromethyl)-2-cyclohexyl-1,3-oxazoleYield 2.7%

Procedure

In substantially the same manner as in Reference Example 31, cyclohexanecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-cyclohexyloxazole as an oily product. The yield was 2.7%.

Sources & evidence

ORD record: ord-d7254fecd64b4a98a96fe9f4615ee5dd
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211215B1

Linked notes

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