1,3-Dichloroacetone → HCID 22009841, compound
Reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH2:9])=[O:8])=[CH:4][CH:3]=1.[Cl:10][CH2:11][C:12]([CH2:14]Cl)=O>>[Cl:10][CH2:11][C:12]1[N:9]=[C:7]([C:5]2[S:6][C:2]([Cl:1])=[CH:3][CH:4]=2)[O:8][CH:14]=1Participants
3
Procedure
In substantially the same manner as in Reference Example 47, 5-chloro-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(5-chloro-2-thienyl)oxazole. The yield was 51%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 90-91° C.
Sources & evidence
- ORD record
- ord-ca571d66ea8e46328eeb687e4f348840
- Source dataset
- uspto-grants-2001_04
- Patent number
- US06211215B1
Reaction notes
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