1,3-Dichloroacetone → 4-Chloromethyl-2-(2-furyl)oxazole

HRID 322282

Reaction equation

[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH2:8])=[O:7].[Cl:9][CH2:10][C:11]([CH2:13]Cl)=O>>[Cl:9][CH2:10][C:11]1[N:8]=[C:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)[O:7][CH:13]=1

Participants

Reactant 2

HCID 107931,3-Dichloroacetone

HCID 69108Furamide

Product 1

HCID 220097064-Chloromethyl-2-(2-furyl)oxazoleYield 47%

Procedure

In substantially the same manner as in Reference Example 47, 2-furancarboxamide was aollowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(2-furyl)oxazole. The yield was 47%. Oily substance.

Sources & evidence

ORD record: ord-a3a7a58566c24585b29f4c2dc2214ffc
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211215B1

Linked notes

Loading…