1,3-Dichloroacetone → HCID 22009832, compound

HRID 322284

Reaction equation

HRID 322284 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH2:9])=[O:8].[Cl:10][CH2:11][C:12]([CH2:14]Cl)=O>>[Cl:10][CH2:11][C:12]1[N:9]=[C:7]([C:3]2[S:4][CH:5]=[CH:6][C:2]=2[CH3:1])[O:8][CH:14]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 5881283-Methylthiophene-2-carboxamide

Product 1

HCID 22009832HCID 22009832, compoundYield 61%

Procedure

In substantially the same manner as in Reference Example 47, 3-methyl-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3-methyl-2-thienyl)oxazole. The yield was 61%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 95-96° C.

Sources & evidence

ORD record
ord-6e3384b4939f4fcf97b097459e830109
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Linked notes

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