1,3-Dichloroacetone → HCID 22009585, compound
Reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH2:9])=[O:8].[Cl:10][CH2:11][C:12]([CH2:14]Cl)=O>>[Cl:10][CH2:11][C:12]1[N:9]=[C:7]([C:3]2[S:4][CH:5]=[CH:6][C:2]=2[Cl:1])[O:8][CH:14]=1Participants
3
Procedure
In substantially the same manner as in Reference Example 47, 3-chloro-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3-chloro-2-thienyl)oxazole. The yield was 54%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 84-85° C.
Sources & evidence
- ORD record
- ord-a2daf1b86cfa43faa7e636f2aff2bf74
- Source dataset
- uspto-grants-2001_04
- Patent number
- US06211215B1
Reaction notes
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