Aluminium lithium hydride → 3-(6-Methoxypyridin-3-yl)propan-1-ol

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11](OC)=[O:12])=[CH:5][N:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][OH:12])=[CH:5][N:4]=1

Participants

Reactant 2

HCID 21226445Aluminium lithium hydride

HCID 22009636Methyl 3-(2-methoxy-5-pyridyl)propionate

Product 1

HCID 215852063-(6-Methoxypyridin-3-yl)propan-1-ol

Procedure

In substantially the same manner as in Reference Example 82, methyl 3-(2-methoxy-5-pyridyl)propionate was reduced by lithium aluminum hydride to give 3-(2-methoxy-5-pyridyl)propanol. The yield was quantative. Oily substance.

Sources & evidence

ORD record: ord-8fbef7b206a04e5b82548c87d216dfa9
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211215B1

Reaction notes

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