Methanesulfonyl chloride → 3-(2-Methoxy-5-pyridyl)propyl methanesulfonate

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][OH:12])=[CH:5][N:4]=1.[CH3:13][S:14](Cl)(=[O:16])=[O:15]>>[CH3:13][S:14]([O:12][CH2:11][CH2:10][CH2:9][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[N:4][CH:5]=1)(=[O:16])=[O:15]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 215852063-(6-Methoxypyridin-3-yl)propan-1-ol

Product 1

HCID 220098553-(2-Methoxy-5-pyridyl)propyl methanesulfonate

Procedure

In substantially the same manner as in Reference Example 85, 3-(2-methoxy-5-pyridyl)propanol was reacted with methanesulfonyl chloride to give 3-(2-methoxy-5-pyridyl)propyl methanesulfonate. The yield was quantative. Oily substance.

Sources & evidence

ORD record: ord-0488d9e9dfa54ad5bcaaf6378103392a
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211215B1

Reaction notes

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