1-[3-(3-Hydroxyphenyl)propyl]imidazole → 2-(4-Benzyloxyphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole

Participants

Role	Name	HCID	Charge
Reactant	1-[3-(3-Hydroxyphenyl)propyl]imidazole	HCID 22009809	—
Reactant	2-(4-Benzyloxy-phenyl)-4-chloromethyl-oxazole	HCID 22009845	—
Product	2-(4-Benzyloxyphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole	HCID 22009625	81%

Reaction Steps

In substantially the same manner as in Working Example 72, 1-[3-(3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 2-(4-benzyloxyphenyl)-4-chloromethyloxazole to give 2-(4-benzyloxyphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 81%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 144-145° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06211215B1
Source dataset	uspto-grants-2001_04
ORD ID	ord-b40a9129cf504fcc8cbcba254d087a33
Source note	uspto-grants-2001_04