HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-phenyl-1,3-oxazole → 4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-phenyloxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-phenyl-1,3-oxazole | HCID 3551196 | — |
| Reactant | 1-[4-(4-Hydroxyphenyl)butyl]imidazole | HCID 22009664 | — |
| Product | 4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-phenyloxazole | HCID 22009763 | 89% |
Reaction Steps
In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-phenyloxazole to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-phenyloxazole. The yield was 89%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 113-114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-5aa711f16bac4fe584b4bbafee5d3270 |
| Source note | uspto-grants-2001_04 |