Benzeneacetic acid, 4-bromo- → 2-[(4-Bromophenyl)acetamido]butyric acid isobutyl ester

HRID 322658

Reaction equation

HRID 322658 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 74654Benzeneacetic acid, 4-bromo-HCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 155476402-[(4-Bromophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I′ above and using 4-bromophenylacetic acid (Aldrich) and isobutyl 2-aminobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-545f57cc0832429bb81b73ba9c1b1060
Source dataset
uspto-grants-2001_04
Patent number
US06211235B1

Linked notes

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