3-Chlorophenylacetic acid → 2-[(3-Chlorophenyl)acetamido)butyric acid iso-butyl ester

HRID 322659

Reaction equation

HRID 322659 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 158793-Chlorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 155476412-[(3-Chlorophenyl)acetamido)butyric acid iso-butyl ester

Procedure

Following General Procedure I′ above and using 3-chlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure. NMR data was as follows:

Workup

  1. customprepared

Sources & evidence

ORD record
ord-2cb2eb909cf24a3f9208b26813f34f72
Source dataset
uspto-grants-2001_04
Patent number
US06211235B1

Linked notes

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