3,5-Difluorophenylacetic acid → N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=1)[CH:14]([CH3:16])[CH3:15]Participants
3
Procedure
Following General Procedure I′ above, and using 3,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.
Workup
- customprepared
Sources & evidence
- ORD record
- ord-99d28e85a23147c2a10d70f8dc79ecbd