Alanine methyl ester hydrochloride → N-[N-(Phenylacetyl)-L-alaninyl]-L-alanine Methyl Ester

HRID 322774

Reaction equation

HRID 322774 reaction equation
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:13]([OH:15])=O)[CH3:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:17][O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH2:21]>>[CH3:17][O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH:21][C:13](=[O:15])[C@H:11]([CH3:12])[NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 2733257Alanine methyl ester hydrochlorideHCID 7004640N-(Phenylacetyl)-L-alanine

Product 1

HCID 22895047N-[N-(Phenylacetyl)-L-alaninyl]-L-alanine Methyl Ester

Procedure

Following General Procedure A and using N-(phenylacetyl)-L-alanine (from Example B1 above) and L-alanine methyl ester hydrochloride (Aldrich), the title compound was prepared as a solid (mp=140.5-142° C.). The reaction was monitored by tlc (Rf=0.17 in 50% EtOAc/hexanes).

Sources & evidence

ORD record
ord-770776c15ebd4bdbadd2052308294f48
Source dataset
uspto-grants-2001_04
Patent number
US06211235B1

Linked notes

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