2-Anilino4-(2-formyl-1-isopropylimidazol-5-yl)pyrimidine → 2-Anilino-4-[2-(pyridin-4-ylcarbonyl)-1-isopropylimidazol-5-yl]pyrimidine

HRID 32346

Reaction equation

HRID 32346 reaction equation
[NH:1]([C:8]1[N:13]=[C:12]([C:14]2[N:18]([CH:19]([CH3:21])[CH3:20])[C:17]([CH:22]=[O:23])=[N:16][CH:15]=2)[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N(C1N=C(C2[N:41](C(C)C)[C:40]([C:45]([C:47]3SC=[CH:50][CH:51]=3)=O)=NC=2)C=CN=1)C1C=CC=CC=1>>[NH:1]([C:8]1[N:13]=[C:12]([C:14]2[N:18]([CH:19]([CH3:20])[CH3:21])[C:17]([C:22]([C:47]3[CH:45]=[CH:40][N:41]=[CH:50][CH:51]=3)=[O:23])=[N:16][CH:15]=2)[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 116381022-Anilino4-(2-formyl-1-isopropylimidazol-5-yl)pyrimidineHCID 692221052-Anilino-4-[2-(thien-2-ylcarbonyl)-1-isopropylimidazol-5-yl]pyrimidine

Product 1

HCID 98648702-Anilino-4-[2-(pyridin-4-ylcarbonyl)-1-isopropylimidazol-5-yl]pyrimidine

Procedure

The title compound was prepared by the procedure of Example 6 from 2-anilino-4-(2-formyl-1 -isopropylimidazol-5-yl)pyrimidine (Example 10) and N-methoxy-N-methyl 4-pyridinecarboxamide (Method 7). NMR (CDCl3): 1.55-1.75 (m, 10H), 5.56-5.72 (sept, 1H), 6.98 (d, 1H), 7.10 (t, 1H), 7.20 (br s, 1H), 7.30-7.40 (m, 2H), 7.55 (s, 1H) (7.60 (d, 2H), 7.90-7.94 (m, 2H), 8.51 (d, 1H), 8.78-8.82 (m, 2 H); m/z 385.

Sources & evidence

ORD record
ord-0c90a0da42dc4b79bf45c97622c5ea35
Source dataset
uspto-grants-2008_09
Patent number
US07427626B2

Linked notes

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