Magnesium Bromide → 2-(2,2,2-Trifluoroethoxy)ethan-1-ol
Reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][O:7]C1CCCCO1.[Br-].[Mg+2].[Br-]>C(OCC)C>[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][OH:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Combine 2-tetrahydropyran-2-yloxyethyl 2,2,2-trifluorethyl ether (2 mmol) and magnesium bromide (6 mmol) in diethyl ether (10 mL). After 24 hours, extract with water and then brine. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give 2-hydroxyethyl 2,2,2-trifluorethyl ether.
Workup
- extractionextract with water
- dry with materialDry the organic layer over Na2SO4
- filtrationfilter
- concentrationconcentrate in vacuo
Sources & evidence
- ORD record
- ord-548a260dea404a5c8c1788cbebc98700
- Source dataset
- uspto-grants-2001_04
- Patent number
- US06211199B1
Reaction notes
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