5-Chloro-2-(piperidin-4-yloxy)pyridine → 5-[({4-[(5-Chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dione

HRID 32393

Reaction equation

HRID 32393 reaction equation
[O:1]=[C:2]1[NH:6][C:5]([CH2:18][S:19](Cl)(=[O:21])=[O:20])([CH2:7][N:8]2[C:12](=[O:13])[C:11]([CH3:15])([CH3:14])[N:10]([CH3:16])[C:9]2=[O:17])[C:4](=[O:23])[NH:3]1.[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([O:31][CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[N:29][CH:30]=1>>[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([O:31][CH:32]2[CH2:37][CH2:36][N:35]([S:19]([CH2:18][C:5]3([CH2:7][N:8]4[C:12](=[O:13])[C:11]([CH3:15])([CH3:14])[N:10]([CH3:16])[C:9]4=[O:17])[NH:6][C:2](=[O:1])[NH:3][C:4]3=[O:23])(=[O:21])=[O:20])[CH2:34][CH2:33]2)=[N:29][CH:30]=1

Participants

3

Reactant 2

HCID 112643295-Chloro-2-(piperidin-4-yloxy)pyridineHCID 23133523Racemic {2,5-dioxo-4-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidin-4-yl}methanesulfonyl chloride

Product 1

HCID 231334915-[({4-[(5-Chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dione

Procedure

The title compound was prepared as described in Example 12 from racemic {2,5-dioxo-4-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidin-4-yl}methanesulfonyl chloride and 5-chloro-2-(piperidin-4-yloxy)-pyridine.

Sources & evidence

ORD record
ord-2c292d5db70444ad8630d8c141ce7b99
Source dataset
uspto-grants-2008_09
Patent number
US07427631B2

Linked notes

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