Methanol → 4-Hydroxy-6-methyl-2-pyrone

HRID 323935

Reaction equation

[C:1]([OH:13])(=[O:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]CCC(O)=O.C[OH:15]>>[OH:15][C:3]1[CH:4]=[C:5]([CH3:6])[O:12][C:1](=[O:13])[CH:2]=1

Participants

Reactant 2

HCID 887Methanol

HCID 2266Azelaic Acid

Product 1

HCID 546757574-Hydroxy-6-methyl-2-pyrone

Procedure

Similar to Example 150, 6.81 g (21.9 mmol, 73%) of a methyl ester compound was obtained as orange crystals from 6.08 g (0.0 mmol recrystallized from 3 methanol) of monomethyl ester of azelaic acid and 3.78 g (30.0 mmol) of 4-hydroxy-6-methyl-2-pyrone by recrystallization from methanol.

Sources & evidence

ORD record: ord-ba00ba0e1f664119be5756240563bc16
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06215016B1

Linked notes

Loading…