HCID 85980352, compound → 1-Phenyl-4-(pyridin-4-yl)butylamine

Reaction equation

[H][H].[C:3]1([C:9](=[N:19]O)[CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>>[C:3]1([CH:9]([NH2:19])[CH2:10][CH2:11][CH2:12][C:13]2[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 85980352HCID 85980352, compound

HCID 178418361HCID 178418361, compound

Product 1

HCID 655846421-Phenyl-4-(pyridin-4-yl)butylamineYield 88.4%

Procedure

Using deprotection method A under 4.1 bar (60 psig) of hydrogen, 1-phenyl-4-(pyridin-4-yl)butan-1-one oxime (1.6 g, 6.5 mmol) afforded 1.3 g (87%) of the title compound.

Sources & evidence

ORD record: ord-dc20a0ed308e4c96af8685a6c280c0d1
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07427632B2

Reaction notes

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