HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(9-Fluorenylmethoxycarbonyloxy)succinimide → n-[(r)-2-[(9h-Fluoren-9-ylmethoxycarbonyl)(1-isopropyl-piperidin-4-ylmethyl)amino]-1-phenylethyl]carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(9-Fluorenylmethoxycarbonyloxy)succinimide | HCID 134122 | — |
| Reactant | N-[(R)-2-[(1-Isopropylpiperidin-4-ylmethyl)amino]-1-phenyl-ethyl]carbamic acid tert-butyl ester | HCID 69307988 | — |
| Product | n-[(r)-2-[(9h-Fluoren-9-ylmethoxycarbonyl)(1-isopropyl-piperidin-4-ylmethyl)amino]-1-phenylethyl]carbamic acid tert-butyl ester | HCID 69309681 | 113.5% |
Reaction Steps
Using coupling method B, N-[(R)-2-[(1-isopropylpiperidin-4-ylmethyl)amino]-1-phenylethyl]carbamic acid tert-butyl ester (1.1 g, 2.8 mmol) and 9-fluorenylmethyl N-succinimidyl carbonate (Fmoc-OSu, 962 mg, 2.9 mmol) afforded 1.9 g of the title compound as a crude residue, that was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-e4a11d44c2f74fedb928844e4d48c9a0 |
| Source note | uspto-grants-2008_09 |