3-Thiophen-2-ylprop-2-enoic acid → 3-(2-Thienyl)propanoic acid

HRID 324773

Reaction equation

HRID 324773 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([OH:10])=[O:9]>C(O)C.[Pd]>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([OH:10])=[O:9]

Participants

4

Reactant 1

HCID 928683-Thiophen-2-ylprop-2-enoic acid

Product 1

HCID 7031693-(2-Thienyl)propanoic acidYield 77.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 3-(2-thienyl)acrylic acid (7 g) in ethanol was added 5% palladium on carbon and the mixture was hydrogenated at 50 psi in a Parr apparatus. The catalyst was filtered off and the solvent was removed by evaporation to yield the title compound (5.5 g) as an oil. Electrospray MS m/z 155 [M−H]+.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed by evaporation

Sources & evidence

ORD record
ord-1d78723a0ed54ea097bab6291d5bbe04
Source dataset
uspto-grants-2001_04
Patent number
US06218538B1

Linked notes

Loading…