Benzylamine → N-Benzyl-2-chloro-9-isopropyl-9H-purin-6-amine

HRID 324978

Reaction equation

HRID 324978 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])=[C:4](Cl)[N:3]=1.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(O)CCC>[CH2:15]([NH:22][C:4]1[N:3]=[C:2]([Cl:1])[N:10]=[C:9]2[C:5]=1[N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 112184902,6-dichloro-9-(propan-2-yl)-9H-purine

Product 1

HCID 10733091N-Benzyl-2-chloro-9-isopropyl-9H-purin-6-amineYield 85%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

2,6-dichloro-9-isopropylpurine (1 mmol) and benzylamine (3,5 mmol) were heated with stirring in 3 ml of n-butanol (3 hour, 110° C.). The reaction mixture (after evaporation of n-butanol) was worked up as above for the compound 2, yield 85-90%.

Workup

  1. customThe reaction mixture (after evaporation of n-butanol)

Sources & evidence

ORD record
ord-ac9cf80d86554577856267a8dbe0d929
Source dataset
uspto-grants-2001_04
Patent number
US06221873B1

Linked notes

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