N-acetoacetylaspartic acid → N-acetoacetyl-L-aspartic anhydride

HRID 325268

Reaction equation

HRID 325268 reaction equation
[C:1]([NH:7][C@H:8]([C:13]([OH:15])=[O:14])[CH2:9][C:10]([OH:12])=O)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]>C(O)(=O)C.C(OC(=O)C)(=O)C>[C:1]([NH:7][C@@H:8]1[C:13](=[O:14])[O:15][C:10](=[O:12])[CH2:9]1)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]

Participants

4

Reactant 1

HCID 13334672N-acetoacetylaspartic acid

Product 1

HCID 13334674N-acetoacetyl-L-aspartic anhydride

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 7918Acetic AnhydrideSolvent

Procedure

1.41 parts of N-acetoacetyl-L-aspartic acid were dissolved in 25 parts by volume of acetic acid, and 5 parts by volume of acetic anhydride were added and the mixture was stirred overnight under nitrogen. Solvent was removed under vacuum at 40°-45° C. 50 parts by volume of acetic acid were added and the evaporation repeated to form N-acetoacetyl-L-aspartic anhydride.

Workup

  1. additionwere added
  2. customSolvent was removed under vacuum at 40°-45° C
  3. addition50 parts by volume of acetic acid were added
  4. customthe evaporation

Sources & evidence

ORD record
ord-fda6fcb956c94610a096d5bdb36c6ec2
Source dataset
uspto-grants-1984_04
Patent number
US04440677

Linked notes

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