N-(2-Acetylthio-3-chlorobenzoyl)-N-cyclopentylglycine → N-(3-Chloro-2-sulfanylbenzoyl)-N-cyclopentylglycine
Reaction equation
C([S:4][C:5]1[C:22]([Cl:23])=[CH:21][CH:20]=[CH:19][C:6]=1[C:7]([N:9]([CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH2:10][C:11]([OH:13])=[O:12])=[O:8])(=O)C>N>[SH:4][C:5]1[C:22]([Cl:23])=[CH:21][CH:20]=[CH:19][C:6]=1[C:7]([N:9]([CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH2:10][C:11]([OH:13])=[O:12])=[O:8]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
To a chilled solution of methanolic ammonia (50 ml) was added 3.7 g (0.0104 m) of N-(2-acetylthio-3-chlorobenzoyl)-N-cyclopentylglycine. The reaction was covered with nitrogen and stirred 3 hours while warming slowly from 0° C. to room temperature.
Workup
- temperaturewhile warming slowly from 0° C. to room temperature