3-N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-oxo-1,2,5-thiadiazole-3,4-diamine → HCID 13458067, compound
Reaction equation
NC1C(NCCSCC2C=C(CN(C)C)SC=2)=NS(=O)N=1.[NH2:22][C:23]1[C:27]([NH:28][CH2:29][CH2:30][S:31][CH2:32][C:33]2[O:34][C:35]([CH2:38][N:39]([CH3:41])[CH3:40])=[CH:36][CH:37]=2)=[N:26][S:25](=O)[N:24]=1>>[NH2:22][C:23]1[C:27]([NH:28][CH2:29][CH2:30][S:31][CH2:32][C:33]2[O:34][C:35]([CH2:38][N:39]([CH3:41])[CH3:40])=[CH:36][CH:37]=2)=[N:26][S:25][N:24]=1Participants
3
Procedure
The general procedure of Example 5 is repeated except that the 3-amino-4-{2-[(5-dimethylaminomethyl-3-thienyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide utilized therein is replaced by an equimolar amount of 3-amino-4-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide [prepared according to U.S. Pat. No. 4,374,248], and the title compound is thereby produced. Treatment of a portion of the product with an equivalent amount of 2 N HCl in methanol produces the hydrochloride salt of the title compound.
Workup
- customprepared