1,2-Ethanediamine, N1,N2-bis(phenylmethyl)-, acetate (1:2) → Benzathine

HRID 326062

Reaction equation

HRID 326062 reaction equation
C(O)(=O)C.C(O)(=O)C.[CH2:9]([NH:16][CH2:17][CH2:18][NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>O>[CH2:9]([NH:16][CH2:17][CH2:18][NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 1

HCID 312281,2-Ethanediamine, N1,N2-bis(phenylmethyl)-, acetate (1:2)

Product 1

HCID 8793Benzathine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

306 mg. (0.001 ml) of BL-P2013 was dissolved in 7 ml. H2O and added to a solution of 180 mg. (0.0005 mol) of N,N'-dibenzylethylenediamine diacetate in 7 ml. H2O. The mixture was stirred and the salt crystallized and after stirring approximately 10-15 minutes the salt was collected by filtration and air dried to yield N,N'-dibenzylethylenediamine salt of BL-P2013 (300 mg). The material was recrystallized by dissolving it in approximately 10 ml. of boiling acetone and diluting with ether to the cloud point. 260 mg. of air dried and vacuum dried material was obtained.

Workup

  1. customthe salt crystallized
  2. stirringafter stirring approximately 10-15 minutes the salt
  3. filtrationwas collected by filtration and air
  4. customdried

Sources & evidence

ORD record
ord-794f9ad4822a4f868355d1e59d69d996
Source dataset
uspto-grants-1984_04
Patent number
US04444687

Linked notes

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