Acetic Acid → N-(3-formyl-2-methylphenyl)acetamide
Reaction equation
[CH3:1][C:2]1[C:9]([NH2:10])=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#N.[C:11](OC(=O)C)(=[O:13])[CH3:12].C(O)(=[O:20])C>>[CH3:1][C:2]1[C:9]([NH:10][C:11](=[O:13])[CH3:12])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:20]Participants
4
Procedure
39 g (0.3 mole) of 2-methyl-3-amino-benzonitrile were dissolved in 75 ml of acetic acid, 30 ml (0.3 mole) of acetic anhydride were added, the mixture was heated with reflux for 5 minutes, and cooled. The solid obtained was filtered off an the evaporation of the solvent furnished an additional quantity of solid which was added to the preceding one. After recrystallisation of the whole from toluene, 44 g (95%) of colourless flakes were obtained, with a melting point of 160° C.
Workup
- temperaturethe mixture was heated
- temperaturewith reflux for 5 minutes
- temperaturecooled
- customThe solid obtained
- filtrationwas filtered off an
- customthe evaporation of the solvent
- customfurnished an additional quantity of solid which
- additionwas added to the preceding one
- customAfter recrystallisation of the whole from toluene, 44 g (95%) of colourless flakes
- customwere obtained, with a melting point of 160° C.
Sources & evidence
- ORD record
- ord-d739e76f6b5e48e680805541cff11c6f
- Source dataset
- uspto-grants-1984_04
- Patent number
- US04444776
Reaction notes
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