Gentamicin Sulfate → Gentamicin C1

HRID 326524

Reaction equation

HRID 326524 reaction equation
CC(N)[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)CC1.[CH3:33][CH:34]([NH:64][CH3:65])[C@H:35]1[O:40][C@H:39]([O:41][C@H:42]2[C@H:47]([OH:48])[C@@H:46]([O:49][C@H:50]3[O:55][CH2:54][C@@:53]([OH:57])([CH3:56])[C@H:52]([NH:58][CH3:59])[C@H:51]3[OH:60])[C@H:45]([NH2:61])[CH2:44][C@@H:43]2[NH2:62])[C@H:38]([NH2:63])[CH2:37][CH2:36]1.C[C@@]1(O)[C@H](NC)[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC1.OS(O)(=O)=O>O>[CH3:33][C@@H:34]([NH:64][CH3:65])[C@H:35]1[O:40][C@H:39]([O:41][C@H:42]2[C@H:47]([OH:48])[C@@H:46]([O:49][C@H:50]3[O:55][CH2:54][C@@:53]([OH:57])([CH3:56])[C@H:52]([NH:58][CH3:59])[C@H:51]3[OH:60])[C@H:45]([NH2:61])[CH2:44][C@@H:43]2[NH2:62])[C@H:38]([NH2:63])[CH2:37][CH2:36]1

Participants

3

Reactant 1

HCID 9855350Gentamicin Sulfate

Product 1

HCID 72395Gentamicin C1

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Foam wound materials containing gentamicin sulfate were prepared as shown in Example 1. Once materials were prepared they were placed onto grid supports and maintained at room temperature. All were covered with a foil wrap. Every 12 hours for nine days, 5 ml of water was applied onto the foam bandage materials and eluent was collected. Two ml samples containing SDMC entrapped gentamicin were assayed for gentamicin antibiotic activity using standard antimicrobial assays. The results are shown in Table X.

Workup

  1. customwere prepared
  2. customOnce materials were prepared they
  3. customwas collected
  4. additionTwo ml samples containing SDMC

Sources & evidence

ORD record
ord-61ffb64a2f9e4313bead49399f835953
Source dataset
uspto-grants-1993_12
Patent number
US05269979

Linked notes

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