HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic Acid → 2-Chloro-5-cyclopropylmethanesulfonyl-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Iodine | HCID 807 | — |
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 2-Chloro-5-sulfino-benzoic acid | HCID 15112904 | — |
| Solvent | Cyclopropanemethanol | HCID 75644 | — |
| Product | 2-Chloro-5-cyclopropylmethanesulfonyl-benzoic acid | HCID 43560564 | 8% |
Reaction Steps
The title compound was synthesised according to the procedure described for the synthesis of 2-Chloro-5-methanesulfonyl)-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and Bromomethyl-cyclopropane (+catalytic amount I2) in 20 ml cyclopropyl methanol/20 ml water and obtained in 8% yield. MS (m/e): 273.1 (MH−, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427612B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-6074aae533fb4a4fa4fccb4f830f50df |
| Source note | uspto-grants-2008_09 |