Acetic Anhydride → 2-Methoxymethyl-4(3H)-pteridinone

HRID 326825

Reaction equation

HRID 326825 reaction equation
[NH2:1][C:2]1[C:3]([C:8]([NH2:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.[C:11]([O:14][C:15](=O)C)(=O)[CH3:12]>C(O)C>[CH3:15][O:14][CH2:11][C:12]1[NH:10][C:8](=[O:9])[C:3]2[C:2](=[N:7][CH:6]=[CH:5][N:4]=2)[N:1]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 280292Aminopyrazine carboxamide

Product 1

HCID 1355070222-Methoxymethyl-4(3H)-pteridinone

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Obtained using the procedure described in Example 1, starting with 11.7 g (0.085 mole) of 3-amino-2-pyrazinecarboxamide, 73.0 g (0.38 mole) of triethyl orthomethoxyacetate [prepared according to E. T. Stiller, U.S. Pat. No. 2,422,598; C.A. 1947, 41, 5904a] and 75 ml of acetic anhydride. Yld: 12.3 g (75%), m.p. 187°-189° C. (ethanol).

Workup

  1. customObtained
  2. customprepared

Sources & evidence

ORD record
ord-2efa70dae48e40678b29a1b2d61e0afa
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Linked notes

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