HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Amino-2-[(4-chlorophenoxy)methyl]pteridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3-Aminopyrazine-2-carbonitrile | HCID 817699 | — |
| Reactant | 2-(4-Chlorophenoxy)ethanimidamide | HCID 2735787 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Amino-2-[(4-chlorophenoxy)methyl]pteridine | HCID 10755749 | — |
Reaction Steps
Obtained using the procedure described in section c of Example 2, starting with 10.7 g (0.089 mole) of 3-amino-2-pyrazinecarbonitrile and 24.5 g (0.133 mole) of 2-(4-chlorophenoxy)acetamidine [prepared according to C. Djerassi and C. R. Scholz, U.S. Pat. No. 2,517,468; C.A. 1951, 45, 661f] in 320 ml of absolute ethanol. Refluxing time: 7 hours. Yld: 21.5 g (84%), m.p. 246°-248° C. (N,N-dimethylformamide).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05270465 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-80961a04363848518e55b6a7f3125464 |
| Source note | uspto-grants-1993_12 |