2-Morpholin-4-yl-5-nitro-benzoyl chloride → [4-(2-Chloro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(2-morpholin-4-yl-5-nitro-phenyl)-methanone

HRID 32704Notes

Reaction equation

HRID 32704 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[N:18]1([C:24]2[CH:32]=[CH:31][C:30]([N+:33]([O-:35])=[O:34])=[CH:29][C:25]=2[C:26](Cl)=[O:27])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][N:15]([C:26]([C:25]2[CH:29]=[C:30]([N+:33]([O-:35])=[O:34])[CH:31]=[CH:32][C:24]=2[N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[O:27])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 172741532-Morpholin-4-yl-5-nitro-benzoyl chlorideHCID 468374961-[2-Chloro-4-(trifluoromethyl)phenyl]piperazine

Product 1

HCID 59793524[4-(2-Chloro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(2-morpholin-4-yl-5-nitro-phenyl)-methanone

Procedure

The title compound was prepared according to the procedure described for example 46 from 1-(2-Chloro-4-trifluoromethyl-phenyl)-piperazine and 2-Morpholin-4-yl-5-nitro-benzoyl chloride (74%, yellow solid, MS (m/e): 499.2 (M+H, 100%)

Sources & evidence

ORD record
ord-c34b2430246247cfb9fb1feab3edbe77
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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