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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 32713Generated: October 24, 2026

1-(2-Fluorophenyl)piperazine → (2-Fluoro-5-nitro-phenyl)[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

https://huagongshe.com/en/reaction/32713

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Fluorophenyl)piperazineHCID 70529—
Reactant2-Fluoro-5-nitrobenzoyl chlorideHCID 10976570—
Product(2-Fluoro-5-nitro-phenyl)[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanoneHCID 59793717—

Reaction Steps

The title compound was prepared according to the procedure described for example 46 from 2-Fluoro-5-nitro-benzoyl chloride and 1-(2-fluorophenyl)-piperazine (52%, orange solid, MS (m/e): 348.1 (M+H, 100%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07427612B2
Source datasetuspto-grants-2008_09
ORD IDord-72e1b6a028d044d0a14fe54c3ba4d0f0
Source noteuspto-grants-2008_09