Acetic Acid → Methyl furan-2-carboximidate

2-Cyanofuran (4.50 g, 48.3 mmol) was dissolved in methanol (25 ml), and sodium methoxide (130 mg, 2.4 mmol) was added under ice-cooling. The mixture was stirred while the temperature is slowly raised up to room temperature for 2 hours. After the reaction was completed, acetic acid (0.16 g, 2.6 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (100 ml) was added to the concentrated residue, and insolubles were removed by filtration The filtrate was concentrated under reduced pressure to give the crude product of methyl 2-furancarboximidate (6.0 g) as a pale yellow oil.

1. temperaturecooling
2. concentrationthe solution was concentrated under reduced pressure
3. additionDiethyl ether (100 ml) was added to the concentrated residue, and insolubles
4. customwere removed by filtration The filtrate
5. concentrationwas concentrated under reduced pressure

ORD record

ord-9c806235fd5c46b2ac9b7b989cd20b7f

Source dataset

uspto-grants-1993_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05272164