Hydrazine → HCID 19380044, compound

HRID 327280

Reaction equation

HRID 327280 reaction equation
C([O:3][C:4]([CH2:6][CH2:7][C:8]1([CH3:18])[O:14][CH:13]([CH3:15])[CH2:12][C:11]([CH3:17])([CH3:16])[O:10][O:9]1)=O)C.[NH2:19][NH2:20].C(OCC)(=O)CCC(C)=O>OC(C)CC(OO)(C)C>[CH3:18][C:8]1([CH2:7][CH2:6][C:4]([NH:19][NH2:20])=[O:3])[O:14][CH:13]([CH3:15])[CH2:12][C:11]([CH3:17])([CH3:16])[O:10][O:9]1

Participants

5

Reactant 3

HCID 9321HydrazineHCID 10883Ethyl levulinateHCID 19380021HCID 19380021, compound2×

Product 1

HCID 19380044HCID 19380044, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 157903394-Hydroperoxy-4-methylpentan-2-olCatalyst

Procedure

3-(1,4,4,6-Tetramethyl-2,3,7-trio-xacycloheptyl)propionhydrazide was prepared by reacting 3-(ethoxycarbonylethyl)-3,5,7,7-tetramethyl-1,2,4-trioxacycloheptane with 9 molar excess of 54% aqueous hydrazine. 3-(Ethoxycarbonylethyl)-3,5,7,7-tetramethyl-1,2,4-trioxacycloheptane was initially prepared in an assay of 89% and a corrected yield of 88% by reacting ethyl levulinate with 10% molar excess of 3-hydroxy-1,1-dimethylbutyl hydroperoxide using 70% aqueous sulfuric acid as a catalyst/dehydrating agent.

Sources & evidence

ORD record
ord-4bbf5a88bec84bb7a2395641487d0b56
Source dataset
uspto-grants-1993_12
Patent number
US05272219

Linked notes

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