Thiomorpholine → (5-Methanesulfonyl-2-thiomorpholin-4-yl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

HRID 32751

Reaction equation

HRID 32751 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[C:12]([N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)[CH2:16][CH2:15]1)=[O:13].[NH:30]1[CH2:35][CH2:34][S:33][CH2:32][CH2:31]1>>[CH3:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([N:30]2[CH2:35][CH2:34][S:33][CH2:32][CH2:31]2)=[C:3]([C:12]([N:14]2[CH2:19][CH2:18][N:17]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)[CH2:16][CH2:15]2)=[O:13])[CH:4]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 67164ThiomorpholineHCID 59793689(2-Chloro-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

Product 1

HCID 68839402(5-Methanesulfonyl-2-thiomorpholin-4-yl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

Procedure

The title compound was prepared according to the procedure described for example 202 from (2-Chloro-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (example BO) and thiomorpholine to yield the title compound as a pale yellow solid. MS (m/e): 514.5 (M+H, 100%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-94a98c0f3a1b432f8125232cf1cfd8b4
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Linked notes

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