HuagongsheHuagongshe Chemistry Print Report · For research reference only
Homophthalic anhydride → (E)-2-[2-[3-[2-[4-(cyclopentyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Homophthalic anhydride | HCID 12801 | — |
| Reactant | (E)-3-[2-[4-(cyclopentyl)-2-thiazolyl]ethenyl]benzeneamine | HCID 15136082 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (E)-2-[2-[3-[2-[4-(cyclopentyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid | HCID 20084332 | 86.8% |
Reaction Steps
A solution of 2.7 g of (E)-3-[2-[4-(cyclopentyl)-2-thiazolyl]ethenyl]benzeneamine, 1.78 g of homophthalic anhydride and 40 ml of toluene was heated to reflux for 0.5 hr. Cooling and filtration yielded 3.75 g of (E)-2-[2-[3-[2-[4-(cyclopentyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid; m.p. 209°-210° C. from tetrahydrofuran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273986 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-41d4e94c979f4fec9dda037206e7a4c8 |
| Source note | uspto-grants-1993_12 |