Chlorosulfamic acid → Benzenepentanol sulfamate

HRID 327669

Reaction equation

HRID 327669 reaction equation
[S:1](Cl)(=[O:4])(=[O:3])[NH2:2].[C:6]1([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][OH:17])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[S:1]([O:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:4])(=[O:3])[NH2:2]

Participants

3

Reactant 2

HCID 24499Chlorosulfamic acidHCID 615235-Phenyl-1-pentanol

Product 1

HCID 19108665Benzenepentanol sulfamate

Procedure

The title compound was prepared by procedures of Example 33 from sulfamoyl chloride and 5-phenyl-1-pentanol. The oil obtained was further purified by chromatography using a column with methylene chloride as eluting agent. Evaporation of appropriate fractions gave a viscous oil which solidified on standing. The solid was recrystallized from ethyl ether-petroleum ether (bp range 30°-60° C.) to give the title compound as white solid, mp 63°-66° C. in 60% yield.

Workup

  1. customThe oil obtained
  2. customwas further purified by chromatography
  3. washas eluting agent
  4. customEvaporation of appropriate fractions
  5. customgave a viscous oil which
  6. customThe solid was recrystallized from ethyl ether-petroleum ether (bp range 30°-60° C.)

Sources & evidence

ORD record
ord-d622221d020a4ad3ac702acd8004e9ad
Source dataset
uspto-grants-1993_12
Patent number
US05273993

Linked notes

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