Benzyl Alcohol → Benzyl sulfamate
Reaction equation
[S:1](Cl)(=[O:4])(=[O:3])[NH2:2].[CH2:6]([OH:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[S:1]([O:13][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:4])(=[O:3])[NH2:2]Participants
3
Procedure
The title compound was prepared by the procedures of Example 33 from sulfamoyl chloride and benzyl alcohol being careful to use reduced pressure at about 35° C. to remove solvents in order to avoid violent decomposition observed in another trial at higher temperature. A white solid, mp 75°-78° C., was obtained in 38% yield.
Workup
- customat about 35° C.
- customto remove solvents in order
- customA white solid, mp 75°-78° C., was obtained in 38% yield
Sources & evidence
- ORD record
- ord-405cbe9ff87f410582b4a75278a1f5a6
- Source dataset
- uspto-grants-1993_12
- Patent number
- US05273993
Reaction notes
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