Chlorosulfonyl isocyanate → Sulfamic acid 3-benzoyl-phenyl ester

HRID 327712

Reaction equation

HRID 327712 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6].Cl[S:17]([N:20]=C=O)(=[O:19])=[O:18]>C1(C)C=CC=CC=1>[C:5]([C:4]1[CH:3]=[C:2]([O:1][S:17](=[O:19])(=[O:18])[NH2:20])[CH:15]=[CH:14][CH:13]=1)(=[O:6])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 70918Chlorosulfonyl isocyanateHCID 830503-Hydroxybenzophenone

Product 1

HCID 44306685Sulfamic acid 3-benzoyl-phenyl esterYield 30.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

This compound was prepared according to the procedure used in Example 84. A mixture of 9.9 g (0.05 mole) of 3-hydroxybenzophenone and 4.4 ml (7.1 g, 0.0505 mole) of chlorosulfonyl isocyanate in 75 ml of toluene gave a solid as residue. This residue was recrystallized successively from benzene and then methylene chloride to yield 4.2 g (30%) of the title compound as a white solid, mp 72°-74° C.

Workup

  1. customThis compound was prepared
  2. customgave a solid as residue
  3. customThis residue was recrystallized successively from benzene

Sources & evidence

ORD record
ord-b0db0bc544d84fe2901daa810e56f1bf
Source dataset
uspto-grants-1993_12
Patent number
US05273993

Linked notes

Loading…