3-[2-[[5-[(Methylsulfonyl)oxy]pentyl]oxy]phenyl]-2-propenoic acid methyl ester → HCID 86747452, compound
Reaction equation
[CH3:1][O:2][C:3](=[O:19])/C=C/C1C=CC=CC=1OCCCCCO.COC(=O)[CH:23]=[CH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[O:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][O:37][S:38]([CH3:41])(=[O:40])=[O:39]>>[CH3:1][O:2][C:3](=[O:19])[C:24]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[O:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][O:37][S:38]([CH3:41])(=[O:39])=[O:40])=[CH2:23]Participants
3
Procedure
Using the procedure of example 32, 1.09 g (4.13 mmol) of (E)-3-[2-[(5-hydroxypentyl)oxy]phenyl]-2-propenoic acid methyl ester was converted into 1.37 g (97%) of (E)-(3-[2-[[5-[(methylsulfonyl)oxy]pentyl]oxy]phenyl]-2-propenoic acid methyl ester, as a yellow oil.
Sources & evidence
- ORD record
- ord-526e5df08b984251b6a1aa7e28159301
- Source dataset
- uspto-grants-1993_12