Benzylamine → HCID 54524014, compound

Reaction equation

C(N)C1C=CC=CC=1.C(OC([NH:19][C@H:20]([C:22]([NH:24][C@H:25]([C:27]([NH:29][C@H:30]([P:32](=[O:35])([OH:34])[OH:33])[CH3:31])=[O:28])[CH3:26])=[O:23])[CH3:21])=O)C1C=CC=CC=1>>[NH2:19][C@H:20]([C:22]([NH:24][C@H:25]([C:27]([NH:29][C@H:30]([P:32](=[O:33])([OH:35])[OH:34])[CH3:31])=[O:28])[CH3:26])=[O:23])[CH3:21]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 54222031HCID 54222031, compound

Product 1

HCID 54524014HCID 54524014, compound

Procedure

In a manner analogous to Example 7(b), starting from the benzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-L-alanyl-L-alanyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(L-alanyl-L-alanylamino)-ethylphosphonic acid of melting point 283°-284° C (decomposition); [α]D20 = -66.8° (c = 0.5% in water).

Sources & evidence

ORD record: ord-0f4e64005bf6442b8476edf8381fc087
Source dataset: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04016148

Reaction notes

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