7-bromo-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine → Benzenesulfonate

HRID 328105

Reaction equation

HRID 328105 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1.[C:21]1([S:27]([O:30][CH2:31][C:32](=O)[CH3:33])(=[O:29])=[O:28])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:32]([CH3:33])[CH2:31][OH:30])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1.[C:21]1([S:27]([O-:30])(=[O:29])=[O:28])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 125708627-bromo-2-hydrazino-5-phenyl-3H-1,4-benzodiazepineHCID 214439712-Oxopropyl benzenesulfonate

Product 2

HCID 91526BenzenesulfonateHCID 739854037-bromo-2-[(2-hydroxy-1-methylethylidene) hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Procedure

In the manner given in Example 1, 7-bromo-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine can be reacted with 2-oxopropyl benzenesulfonate to give 7-bromo-2-[(2-hydroxy-1-methylethylidene) hydrazino]-5-phenyl-3H-1,4-benzodiazepine, benzenesulfonate (ester).

Sources & evidence

ORD record
ord-dab0d27690e141d186e32e5ccf2e7c69
Source dataset
uspto-grants-1977_04
Patent number
US04016165

Linked notes

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