Thionyl Chloride → HCID 178479372, compound
Reaction equation
[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][CH:6]=1)[C:2]([NH2:4])=[NH:3].S(Cl)([Cl:17])=O>>[ClH:17].[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([Cl:17])=[O:14])=[CH:7][CH:6]=1)[C:2]([NH2:4])=[NH:3]Participants
3
Conditions
- Temperature
- 0 °C
Procedure
21 g of 4-guanidino-phenylacetic acid were added to 200 ml of thionyl chloride that had been cooled to 0° C. After 15 minutes at 0° C, the whole was stirred for 15 minutes at room temperature, the product as precipitated with 500 ml of anhydrous ether, filtered off with suction, washed with anhydrous ether and dried under reduced pressure. 24.7 g of 4-guanidino-phenylacetyl chloride hydrochloride melting at 127° to 130° C were obtained.
Workup
- customthe product as precipitated with 500 ml of anhydrous ether
- filtrationfiltered off with suction