2-Oxo-4-pentenoic acid → 7-chloro-2-[(1-carboxy-3-butenylidene)hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1.O=[C:23]([CH2:27][CH:28]=[CH2:29])[C:24]([OH:26])=[O:25]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:23]([C:24]([OH:26])=[O:25])[CH2:27][CH:28]=[CH2:29])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1Participants
3
Procedure
In the manner given in Example 9, 7-chloro-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine can be stirred with 2-oxo-4-pentenoic acid at room temperature to give 7-chloro-2-[(1-carboxy-3-butenylidene)-hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine.
Sources & evidence
- ORD record
- ord-f65f3451206e41de8af68176167616ed
- Source dataset
- uspto-grants-1977_04
- DOI