HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Phenol, 4-(5-decyl-2-pyrimidinyl)- | HCID 135585902 | — |
| Reactant | HCID 178444557 | HCID 178444557 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N,N'-Dicyclohexylurea | HCID 4277 | — |
Reaction Steps
A solution of 35.4 g of 4-(5-decylpyrimidin-2-yl)phenol, 22.5 g of trans-4-pentylcyclohexanecarboxylic acid and 23.4 g of N,N'-dicyclohexylcarbodiimide in 600 ml of dichloromethane is stirred at 20° C. for 12 hours. The N,N'-dicyclohexylurea formed is filtered off, and the filtrate is chromatographed over 5 kg of silica gel using dichloromethane. The product-containing fraction gives 21.5 g of colorless crystals after recrystallization from n-hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04891151 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-52fde18c50ee408583b6415095779c69 |
| Source note | uspto-grants-1990_01 |