Deferiprone → ZINC 3-hydroxy-1,2-dimethylpyrid-4-one

HRID 330065

Reaction equation

HRID 330065 reaction equation
C(N1C=CC=C(O)C1=O)C.[Zn:11].[OH:12][C:13]1[C:18](=[O:19])[CH:17]=[CH:16][N:15]([CH3:20])[C:14]=1[CH3:21]>C(O)C>[OH:12][C:13]1[C:18](=[O:19])[CH:17]=[CH:16][N:15]([CH3:20])[C:14]=1[CH3:21].[Zn:11]

Participants

4

Reactant 2

HCID 2972DeferiproneHCID 70373874ZINC 1-ethyl-3-hydroxypyrid-2-one

Product 1

HCID 70373691ZINC 3-hydroxy-1,2-dimethylpyrid-4-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The procedure described under (A) is followed with 3-hydroxy-1,2-dimethylpyrid-4-one in place of 1-ethyl-3-hydroxypyrid-2-one to give the neutral 2:1 complex from ethanol as a white crystalline solid in essentially quantitative yield, m.p. 190° C. (with decomposition); νmax 1655, 1612 cm-1 ; δ(d6DMSO); 7.53 (d, 1H), 6.20 (d, 1H), 3.70 (s, 3H), 2.33 (s, 3H).

Sources & evidence

ORD record
ord-75c709617744441185b11998ecb3a51b
Source dataset
uspto-grants-1990_01
Patent number
US04894455

Linked notes

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